Cardiovascular system support
Nattokinase is a kind of alkaline serine prostease with strong fibrinolytic and thrombolytic activity, which is secreted by Bacillus natto and discovered by Sumi et al(1). As endogenous fibrinolytic enzyme, nattokinase is functionally similar to husman plasmin
Overview
Nattokinase was reported to lower blood pressure by inhibiting the secretion of angiotensin-converting enzyme I and angiotensin II, and interact with fibrinogen in plasma to reduce blood viscosity, thereby lowering blood pressure (2).
Studies showed that nattokinase attenuates neovascularization in the retinas of mice with oxygen retinopathy (5), thus it can be useful in the treat ment of such diseases as retinopathy of prematurity, diabetic retinopathy, and retinal vein occlusion. Additionally it can be used as a as a vitreous cleavage supplement in the treatment of proliferative vitreoretinal diseases. According to recent studies Nattokinase has various pharmacological effects, such as improving microcirculation and lowering blood pressure (2), anticoagulation (3), preventing atherosclerosis (4), relieving retinal angiogenesis (5), anticancer (6), inhibiting inflammation and oxidative stress (7). In addition to the research of nattokinase in the fields of throm bosis and hypertension treatment, nattokinase can also be used as a drug or adjuvant to treat diseases such Alzheimer’s disease (AD) (8), retinopathy (5) hyperlipidemia (9) and oral mucositis (10).
Features
Provides nutritional support for the maintenance and enhancement of normal healthy endogenous fibrinolysis
Provides nutritional support for the inhibition of inflammation and oxidative stress
Non-GMO material, non-irradiated, safe for daily use
DIRECTION OF USE
Correct usage is essential for achieving the best results from each product. The following guidelines provide clear instructions on how to incorporate the product into a daily routine for optimal benefits.
Take 1 to 2 capsules a day with water or hot water.
FORMULATION
Each product is carefully formulated using a selection of active ingredients, chosen for their quality and efficacy. Find below the precise formulation this supplement :
NUTRITION FACTS
Each product is formulated with carefully selected ingredients to provide targeted health benefits. Below, you'll find the detailed nutritional information, helping you make informed choices about your wellness routine.
Benefit
Each product in our range is designed to offer targeted health benefits. These carefully formulated products utilise scientifically backed ingredients to help you achieve optimal health and wellness in a natural, effective way.
Contra-indication/Warning
When taking any supplement, it’s important to be aware of potential contra-indications or warnings. Although our products are formulated with natural ingredients and backed by science, they may not be suitable for everyone. Please check the ingredients and seek medical advice.
Please observe the recommended daily intake.
Please check the raw material names and do not consume if you have food allergies.
Keep out of reach of children.
Consume as soon as possible after opening.
If you are undergoing treatment, taking medication, are pregnant or breastfeeding, please consult your doctor or
pharmacist before taking this product.
If it does not suit your constitution or if you are not feeling well, please stop using it.
The colour tone may vary depending on the product, but there is no problem with the quality.
Do not use in children under 18 years old during pregnancy and breastfeeding, as well as persons suffering from nervous irritability, insomnia, hypertension
It is not a medicine
Contra-indications:
Individual intolerance to dietary supplement components.
Testing
Each product undergoes rigorous testing to ensure safety, purity, and effectiveness. We utilise advanced testing methods to verify the quality of ingredients, ensuring that every batch meets the highest industry standards for consistency and reliability.
FAQ Product
We have compiled answers to the most frequently asked questions to help you find the information you need. From product details to customer support, our FAQ’s are designed to provide clear answers and assist you in resolving any uncertainties effectively.
Citations
Scientific research is at the core of our product development. Each formulation is carefully supported by peer-reviewed studies to ensure both efficacy and safety. Below is a selection of key scientific references that validate the benefits and functionality of the ingredients.
1. Sumi H., Hamada H., Tsushima H., Mihara H., Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia. 1987;43:1110-1111.
2. Hsia C.-H., Shen M.-C., Lin J.-S., Wen Y.-K., Hwang K.-L., Cham T.-M., Yang N.-C. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr. Res. 2009;29:190-196. doi:
3. Jensen G.S., Lenninger M., Ero M.P., Benson K.F. Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: Results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial. Integr. Blood Press. Control. 2016;9:95-104.
4. Chang C.-H., Chen K.-T., Lee T.-H., Wang C.-H., Kuo Y.-W., Chiu Y.-H., Hsieh C.-L„ Wu C.-J., Chang Y.-L. Effects of natto extract on endothelial injury in a rat model. Acta Med. Okayama. 2010;64:399-406.
5. Huang Z„ Ng T.K., Chen W„ Sun X., Huang D„ Zheng D„ Yi J., Xu Y„ Zhuang X., Chen S. Nattokinase Attenuates Retinal Neovascularization via Modulation of Nrf2/HO-1 and Glial Activation. Investig. Ophthalmol. Vis. Sci. 2021:62:25.
6. Yan Y., Wang Y„ Qian J., Wu S., Ji Y., Liu Y., Zeng J., Gong A. Nattokinase Crude Extract Inhibits Hepatocellular Carcinoma Growth in Mice. J. Microbiol. Biotechnol. 2019;29:1281-1287.
7. Wu H„ Wang Y., Zhang Y., Xu F., Chen J., Duan L„ Zhang T., Wang J., Zhang F. Breaking the vicious loop between inflammation, oxidative stress and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress. Redox Biol. 2020:32:101500.
8. Bhatt P.C., Pathak S., Kumar V., Panda B.P. Attenuation of neurobehavioral and neurochemical abnormalities in animal model of cognitive deficits of Alzheimer's disease by fermented soybean nanonutraceutical. Inflammopharmacology. 2018;26:105-118. doi: 10.1007/S10787-017-0381-9.
9. Park K.-J., Kang J.-l., Kim T.-S., Yeo l.-H. The Antithrombotic and Fibrinolytic Effect of Natto in Hypercholesterolemia Rats. Prev. Nutr. Food Sci. 2012;17:78-82. doi: 10.3746/pnf.2012.17.1.078.
10. Zhang J., Tang Y„ Yuan T„ Yang M., Fang W„ Li L„ Fei F„ Gong A. Nattokinase crude extract enhances oral mucositis healing. BMC Oral Health. 2021 ;21:555. doi: 10.1186/sl 2903-021-01914-4.