Nattokinase is a kind of alkaline serine prostease with strong fibrinolytic and thrombolytic activity, which is secreted by Bacillus natto and discovered by Sumi et al(1). As endogenous fibrinolytic enzyme, nattokinase is functionally similar to husman plasmin
Nattokinase was reported to lower blood pressure by inhibiting the secretion of angiotensin-converting enzyme I and angiotensin II, and interact with fibrinogen in plasma to reduce blood viscosity, thereby lowering blood pressure (2).
Studies showed that nattokinase attenuates neovascularization in the retinas of mice with oxygen retinopathy (5), thus it can be useful in the treat ment of such diseases as retinopathy of prematurity, diabetic retinopathy, and retinal vein occlusion. Additionally it can be used as a as a vitreous cleavage supplement in the treatment of proliferative vitreoretinal diseases. According to recent studies Nattokinase has various pharmacological effects, such as improving microcirculation and lowering blood pressure (2), anticoagulation (3), preventing atherosclerosis (4), relieving retinal angiogenesis (5), anticancer (6), inhibiting inflammation and oxidative stress (7). In addition to the research of nattokinase in the fields of throm bosis and hypertension treatment, nattokinase can also be used as a drug or adjuvant to treat diseases such Alzheimer’s disease (AD) (8), retinopathy (5) hyperlipidemia (9) and oral mucositis (10).
Provides nutritional support for the maintenance and enhancement of normal healthy endogenous fibrinolysis
Provides nutritional support for the inhibition of inflammation and oxidative stress
Non-GMO material, non-irradiated, safe for daily use
Suggested Use:
Take 1-2 capsules once or twice daily, on an empty stomach (at least 1 hour before or 2 hours after a meal) for optimal enzymatic activity.
Note:
Do not use with anticoagulant or antiplatelet medications unless under supervision. Discontinue 5–7 days before surgery.
Please observe the recommended daily intake.
Please check the raw material names and do not consume if you have food allergies.
Keep out of reach of children.
Consume as soon as possible after opening.
If you are undergoing treatment, taking medication, are pregnant or breastfeeding, please consult your doctor or
pharmacist before taking this product.
If it does not suit your constitution or if you are not feeling well, please stop using it.
The colour tone may vary depending on the product, but there is no problem with the quality.
Do not use in children under 18 years old during pregnancy and breastfeeding, as well as persons suffering from nervous irritability, insomnia, hypertension
It is not a medicine
Contra-indications:
Individual intolerance to dietary supplement components.
1. Sumi H., Hamada H., Tsushima H., Mihara H., Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia. 1987;43:1110-1111.
2. Hsia C.-H., Shen M.-C., Lin J.-S., Wen Y.-K., Hwang K.-L., Cham T.-M., Yang N.-C. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr. Res. 2009;29:190-196. doi:
3. Jensen G.S., Lenninger M., Ero M.P., Benson K.F. Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: Results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial. Integr. Blood Press. Control. 2016;9:95-104.
4. Chang C.-H., Chen K.-T., Lee T.-H., Wang C.-H., Kuo Y.-W., Chiu Y.-H., Hsieh C.-L„ Wu C.-J., Chang Y.-L. Effects of natto extract on endothelial injury in a rat model. Acta Med. Okayama. 2010;64:399-406.
5. Huang Z„ Ng T.K., Chen W„ Sun X., Huang D„ Zheng D„ Yi J., Xu Y„ Zhuang X., Chen S. Nattokinase Attenuates Retinal Neovascularization via Modulation of Nrf2/HO-1 and Glial Activation. Investig. Ophthalmol. Vis. Sci. 2021:62:25.
6. Yan Y., Wang Y„ Qian J., Wu S., Ji Y., Liu Y., Zeng J., Gong A. Nattokinase Crude Extract Inhibits Hepatocellular Carcinoma Growth in Mice. J. Microbiol. Biotechnol. 2019;29:1281-1287.
7. Wu H„ Wang Y., Zhang Y., Xu F., Chen J., Duan L„ Zhang T., Wang J., Zhang F. Breaking the vicious loop between inflammation, oxidative stress and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress. Redox Biol. 2020:32:101500.
8. Bhatt P.C., Pathak S., Kumar V., Panda B.P. Attenuation of neurobehavioral and neurochemical abnormalities in animal model of cognitive deficits of Alzheimer's disease by fermented soybean nanonutraceutical. Inflammopharmacology. 2018;26:105-118. doi: 10.1007/S10787-017-0381-9.
9. Park K.-J., Kang J.-l., Kim T.-S., Yeo l.-H. The Antithrombotic and Fibrinolytic Effect of Natto in Hypercholesterolemia Rats. Prev. Nutr. Food Sci. 2012;17:78-82. doi: 10.3746/pnf.2012.17.1.078.
10. Zhang J., Tang Y„ Yuan T„ Yang M., Fang W„ Li L„ Fei F„ Gong A. Nattokinase crude extract enhances oral mucositis healing. BMC Oral Health. 2021 ;21:555. doi: 10.1186/sl 2903-021-01914-4.
